Meet the DBI users
DBI video series about DBI users.
Researchers affiliated at different Danish institutions shared their bioimaging research with our community; highlighting how important is for their work to use DBI core facilities in order to pursue their research, how are they using the services we offer, both equipment and access to the knowledge and expertise of the core facility staff.
Check out our latest interview with Vinay S.N. Mishra, a postdoctoral researcher in the Department of Physics, Chemistry, Pharmacy at Syddansk Universitet - University of Southern Denmark, featured in this issue as a user of DaMBIC (Danish Molecular Biomedical Imaging Center).
August 2025
Vinay S.N. Mishra, a postdoctoral researcher in the Department of Physics, Chemistry, Pharmacy at Syddansk Universitet - University of Southern Denmark, featured in this issue as a user of DaMBIC (Danish Molecular Biomedical Imaging Center).
Vinay´s research explores how pectin, a natural fiber found in the cell walls of fruits and some vegetables, influences the water organization and microstructure in hybrid plant-dairy gels. Using advanced microscopy techniques (STED and FLIM at DaMBIC), the research reveals how different types of pectin affect the gel structure and molecular dynamics in acidified skim milk gels. These insights help identify markers of instability in hybrid food systems and support the development of more stable, sustainable dairy–plant-based products. The goal is to establish a microscopy-based toolbox for quantifying the impact of pectin incorporation on the microstructure and investigating the molecular interactions within this complex matrix. The project MicroTool serves as a foundation for advancing hybrid food systems that balance health, taste, and sustainability, addressing societal demands for a more resilient and responsible food industry.
Danish Molecular Biomedical Imaging Center (DaMBIC) “Access to the advanced microscopy facilities at DaMBIC was critical to the success of my research. While I have prior experience with advanced microscopy techniques and image analysis, working with STED and FLIM required specialized training. Both Prof Jonathan Brewer and Morten Frendø Ebbesen provided invaluable guidance throughout this process. DaMBIC is an environment that inspires excellence and collaboration, and I am confident that any scientist who engages with their team would share the same appreciation. My research would not have been possible without DaMBIC”, stresses Vinay. Academia and Industry partnership The project MicroTool is conducted under the supervision of Adam Cohen Simonsen and Jonathan Brewer, in collaboration with industry partners Ulf Andersen and Matias Via from Arla Foods , and Flemming Møller from IFF. This partnership bridges academia and industry to drive innovation in food technology. As part of this project, three studies have been planned. One has been published:"Quantifying Microstructure and Molecular Dynamics in Plant-Dairy Based Model Gels Using FLIM and STED Microscopy" (https://lnkd.in/dEZzDnJ2 ).
July 2025
Meet the DBI Users!In this issue, we feature Andrea Mancini,a 27-year-old PhD researcher in the Cell Stress and Survival (CSS) group at the Danish Cancer Institute (DCI). Andrea studied biology in Rome and is now in the third year of his PhD at DCI. Andrea is working on a research project that uses the Carl Zeiss Cell Discoverer 7 microscope for automated high-throughput microscopy. Access to this cutting-edge imaging system has been key to advancing his research allowing him to generate high-resolution images that support his experimental hypotheses and help answer his biological questions. "This microscope significantly advanced my research project. Whenever I encountered any issues, the support from the staff was invaluable, especially Chris, who is always available on the second floor at DCI to provide assistance”, says Andrea Mancini. Watch this short video to explore Andrea’s research journey and how he uses the Carl Zeiss Cell Discoverer 7 microscope at DCI.
🔬 The equipment is open access - Reach out to Chris Dinant.
If you are a researcher interested in using the Zeiss Cell Discoverer 7 at the Danish Cancer Institute’s bioimaging facility, please reach out to Chris Dinant, core facility leader at cdi@cancer.dk
With the implementation of DBI-INFRA in 2022 Danish Cancer Institute acquired a Zeiss Cell Discoverer 7 with LSM900 (CD7) automated high-throughput imaging system. Since its installation in February of 2023, it has been booked an average of 100 hours per week. This makes it the most-used system in the DCI bioimaging facility. The equipment is open access to any researcher in Denmark thanks to the support of the Ministry of Higher Education and Science.
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November 2024
In this issue, we interview Rikke Agerskov, a PhD researcher the Department of Science and Environment at Roskilde University (RUC).
Rikke is working on an exciting project utilizing the Olympus scanning confocal microscope at RUC, focusing on how the nervous system affects the embryonic development of the pancreas. Her work aims to make a significant impact on society by advancing basic science through identifying new neuronal-epithelial signaling mechanisms. Understanding the link between the peripheral nervous system and the pancreas will help improve stem cell protocols for producing beta cells and islet organoids, leading to new treatment options for diabetes. Watch this short video to learn more about Rikke’s research journey, her current interdisciplinary project, and how access to advanced microscopy technologies at RUC has empowered her to perform high-resolution imaging of embryonic pancreatic tissue.
If you’re a researcher interested in using the facility for your research, please reach out to Pia Nyeng for more information on accessing the core facility at RUC. Microscope-core.ruc.dk
September 2024
Meet Istvan Balint SzĂĽcs, using DBI-INFRA to investigate spontaneous miscarriage!
We interview Istvan Balint, a PhD researcher from the Center for Chromosome Stability, Michael Lisby group, at the Københavns Universitet, University of Copenhagen.
Istvan is using an automated High Content Screening (HCS) spinning disc confocal microscope at the Center for Advanced Bioimaging (CAB) to perform imaging of sporulating fluorescent yeast tetrads, in order to study oocyte aneuploidy linked to meiotic recombination and non-disjunction (the failure of the chromosomes to separate). This condition can contribute to chromosomal abnormalities and is associated with an increased risk of pregnancy loss or miscarriage. “About 30% of spontaneous miscarriage in women are associated to genetical events that we do not really know what the reason is behind, and we still do not understand the key players on this”, stress Istvan.
December 2023
In this edition, we interview Serhii Kostrikov, a postdoctoral researcher from the Center for Auditory Neuroscience at DTU Health Tech, who has been using the ZEISS Microscopy Light Sheet 7 at the DBI Core Facility for Integrated Microscopy, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, UCPH, University of Copenhagen. His areas of expertise are neurodegeneration, brain vasculature pathology, cancer, and drug delivery using 3D deep microscopy and machine learning-based image analysis. Serhii has used light sheet microscopy for different projects; from brain tumor vasculature and neurodegeneration, to hearing loss and its connection to dementia. Watch this video to learn more about Serhii’s research, and about how access to microscopy technologies at CFIM empowered him to perform 3D imaging of various organs. As Serhii stresses, access to technical expertise from the core facility staff has been essential for his work; from sample preparation to image analysis guidance and support. The Light Sheet 7 was financed by the Novo Nordisk Foundation: Application Calls and Grants. Serhii's work is funded by the William Demant Foundation.
July 2023
Check out our first interview with Associate Professor Kasper Urup Kjeldsen from the Department of Biology at Aarhus University who is using our infrastructure at the Aarhus BioImaging Core Facility for his research. He is hunting for a special type of Archaea (Asgard archaea) that inhabited the muddy sediments of Aarhus Bay.
“I use the LSM800 confocal laser scanning microscope from Zeiss for my project because I need good resolution as we image tiny cells. It is an excellent confocal microscope with great resolution, and in addition to that it has an Airyscan super resolution module that is very straight forward to use, and allows for the higher resolution needed to image small bacteria”, explains Kasper.
October 2023
Marie Bølling Kongsted is a biologist, and her main research focus is to understand the formation and function of the heart. For her research, she is using zebrafish to study cardiac diseases using different genetic mutants. Zebrafish cardiovascular system shares many similarities with that of humans. Marie´s research provides valuable insights into the genetic and molecular mechanisms underlying cardiac diseases that potentially could lead to the development of new therapies and treatments for the patients.
Marie has used the Core Facility for Integrated Microscopy (CFIM) to pursue her research goals. She used a broad range of technologies, including slide scanners, spinning disk, laser-scanning microscopy, and recently, with the Zeiss LS7 microscope, she was able to acquire full 3D hearth imaging at the latter stage of the zebrafish development, which was not possible with conventional confocal and wide-field techniques.